HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Receptor activator of nuclear factor (NF)– B ligand (RANKL) increases vascular permeability: impaired permeability and angiogenesis in eNOS-deficient mice
نویسندگان
چکیده
1Department of Biochemistry, College of Sciences, Yonsei University, Seoul, Republic of Korea; 2Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chunchon, Kangwon-Do, Republic of Korea; 4Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea; 5Seoul Artificial Eye Center, Clinical Research Institute, Seoul National University Hospital, Republic of Korea; 7Department of Structural Analysis, National Cardiovascular Center Research Institute, Osaka, Japan; 6Department of Microbiology, College of Natural Sciences, Chungnam National University, Daejeon, Republic of Korea; 3Division of Molecular Life Science, Ewha Womans University, Seoul, Republic of Korea
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Modulation of the cochaperone AHA1 regulates heat-shock protein 90 and endothelial NO synthase activation by vascular endothelial growth factor.
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Vascular endothelial growth factor (VEGF) not only regulates angiogenesis, vascular permeability, and vasodilation but also promotes vascular inflammation. However, the molecular basis for the proinflammatory effects of VEGF is not understood. We now show that VEGF activates endothelial cell exocytosis of WeibelPalade bodies, releasing vasoactive substances capable of causing vascular thrombosi...
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